The Analyze of Drug Resistance and Study on Mechanisms of Fluconazole Resistance in Clinical Isolates of Candida Glabrata Fluconazole-resistant Candida Albicans Strains Exhibited Cross-resistance to Other Azole Antifungal Agents in Vitro

1、

We present here the crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP121 in complex with the triazole drug fluconazole, revealing a new azole heme ligation mode.

我们提出了肺结核分支杆菌细胞色素P450CYP121与三氮唑类药物氟康唑的复合物的晶体结构，揭示了唑类与亚铁血红素新的结合模式。

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2、

Voriconazole is a second-generation azole antifungal agent that shows the characters of broad-spectrum and strong antibacterial, especially has good efficacy to the infection induced by invasive aspergillus.

伏立康唑（voriconazole）是第2代三唑类抗真菌药，具有抗菌谱广、抗菌效力强的特点，尤其对于侵袭性曲霉菌侵润所致感染疗效好。

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3、

Azole and triazole drugs are cytochrome P450 inhibitors widely used as fungal antibiotics and possessing potent antimycobacterial actiity.

唑类和三氮唑类药物作为细胞色素P450抑制剂广泛被作为抗真菌药物和抗微生物药物使用。

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4、

The azole antifungals, widely prescribed prophylactically, are known to have many drug2013drug interactions.

处方中经常使用的三唑类抗真菌制剂已知有许多药物相互作用。

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5、

Therapeutic Effect of Four Azole Drugs in the Treatment on Tinea Manuum, Pedis, Corporis and Cruris

四种唑类药物外用治疗体股癣、手足癣的疗效观察

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6、

The azole antifungals including imidazoles and triazoles are the mainstay in clinical treatment of fungal infections.

唑类药物是治疗真菌感染的主要用药，按化学结构分为咪唑类和三唑类。

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7、

Cloning and sequencing of the GTP cyclohydrolase ⅰ function region of azole target enzyme gene in artificially induced resistant Candida albicans

白念珠菌人工诱导耐药株唑靶酶三磷酸鸟苷环水解酶Ⅰ功能区的序列分析

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8、

OBJECTIVE: To analysis the marketing of azole antifungal agent during 2003~ 2005 so as to provide references for the research& development of this kind of drugs.

目的：分析2003年～2005年唑类抗真菌药的市场情况，以期对其研发生产及临床应用提供参考。

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9、

Continued surveillance of azole resistance should be maintained to determine the resistance rates and any possible trend of increase in the isolation frequency of resistant strains.

对抗唑类药物的抗药率和分离耐药株频率的可能趋势应继续进行监控。

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10、

Progress of Azole Antifungal Agents

新唑类抗真菌药物研究进展

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11、

Conventional diagnosis of aspergillosis is limited by poor culture yield, and so the true frequency of azole resistance has been unclear.

常规曲霉病诊断方法由于培养能力限制，不能准确测定对唑类药物的耐药水平。

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12、

Observations on the sensitivity of Candida albicans isolates to azole drug in the renal transplant recipients

肾移植术后患者白念珠菌分离株的唑类药物敏感性观测

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13、

Achievements on the Application of Hydrazine and Related Compounds for the Synthesis of Five-Membered Azole Heterocycles

肼类衍生物在五元唑类杂环合成中的应用进展

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14、

The Synthesis of Azole and Tetrazine Compounds and Study on Corrosion Inhibition for Copper in NaHCO_3 Medium

唑类及嗪类化合物的合成及其在碳酸氢钠介质中对铜缓蚀性能的研究

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15、

Marketing of Azole Antifungal Agent During 2003~ 2005

2003年～2005年唑类抗真菌药市场分析

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16、

Among these four additives, only azole inhibitor X2 can reach the peeling strength target.

在这四种有机物中，只有唑类缓蚀剂X2可以达到剥离强度提高15%以上目标。

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17、

Three azole pesticide in the plant has shown unprecedented sterilization effect, make it have a lot use of space.

三唑类农药在植物杀菌方面表现出前所未有的效果，使得它有很大的使用空间。

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18、

Practical Azole Corrosion Inhibitors for Copper and Its alloys

铜及其合金的实用唑类缓蚀剂

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19、

Synthesis and Antifungal Activity of N Azole Substituted Phenyl Ether Derivatives

氮唑取代苯基醚类衍生物的合成及其抗真菌活性

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20、

26 azole compounds were synthesized, among them 22 compounds are firstly reported.

合成了26个二唑类与三唑类化合物，其中22个为新化合物。

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